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KMID : 0614620150660040202
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Korean Journal of Gastroenterology
2015 Volume.66 No. 4 p.202 ~ p.208
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Uric Acid Is a Risk Indicator for Metabolic Syndrome-related Colorectal Adenoma: Results in a Korean Population Receiving Screening Colonoscopy
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김효진:Kim Hyo-Jin
김지은:Kim Jee-Eun/정지혜:Jung Ji-Hye/김은란:Kim Eun-Ran/홍성노:Hong Sung-Noh/장동경:Chang Dong-Kyung/손희정:Sohn Hee Jung/이풍렬:Rhee Poong-Lyul/김재준:Kim Jae-Jun/김영호:Kim Young-Ho
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Abstract
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Background/Aims: An association between serum uric acid and cancer risk has been noted over the past few decades. There is ongoing debate about whether hyperuricemia represents an independent risk factor for colorectal neoplasm. We investigated the association between serum uric acid and prevalence of colorectal adenoma considering numerous confounding factors.
Methods: A cross-sectional study was performed with individuals who underwent a routine health check-up examination, including a screening colonoscopy and blood chemistry. The association between serum uric acid and prevalence of colorectal adenoma was estimated from the results of a logistic regression analysis.
Results: Of the 1,066 participants, 402 had colorectal adenoma (37.7%). In univariate models, the prevalence of colorectal adenoma was higher in participants in the fourth quartile uric acid level, compared to those in the first quartile uric acid level (OR, 1.67; 95% CI, 1.17-2.42; p=0.004). However, no significant association was detected between serum uric acid and prevalence of colorectal adenoma in multiple logistic regression analysis. A number of metabolic syndrome components exhibited a strong association with the prevalence of colorectal adenoma in the multivariate model (OR, 3.46 for highest vs. lowest; 95% CI, 1.30-9.20; p=0.021). Moreover, serum uric acid was strongly associated with metabolic syndrome-associated variables, including waist circumference, fasting blood glucose, systolic blood pressure, diastolic blood pressure, triglyceride, and high-density lipoprotein.
Conclusions: Uric acid is not an independent risk factor for colorectal adenoma but is a risk indicator for metabolic syndrome-related colorectal adenoma.
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KEYWORD
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Colorectal neoplasms, Uric acid, Metabolic syndrome X
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